George Simos Selected Research

Hypoxia-Inducible Factor 1

4/2013	High serum levels of HIF-1α in psoriatic patients correlate with an over-expression of IL-6.
10/2011	Isolation of hypoxia-inducible factor 1 (HIF-1) inhibitors from frankincense using a molecularly imprinted polymer.
9/2010	Casein kinase 1 regulates human hypoxia-inducible factor HIF-1.
7/2010	The dietary flavonoid kaempferol effectively inhibits HIF-1 activity and hepatoma cancer cell viability under hypoxic conditions.
12/2009	Increased HIF-1 alpha immunostaining in psoriasis compared to psoriasiform dermatitides.
11/2008	Prognostic significance of Hypoxia-Inducible Factor 1 alpha(HIF-1 alpha) expression in serous ovarian cancer: an immunohistochemical study.
10/2008	Atypical CRM1-dependent nuclear export signal mediates regulation of hypoxia-inducible factor-1alpha by MAPK.
8/2006	Reconstitution of human hypoxia inducible factor HIF-1 in yeast: a simple in vivo system to identify and characterize HIF-1alpha effectors.

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George Simos Research Topics

Disease

37	Hypoxia (Hypoxemia) 12/2021 - 11/2004
17	Neoplasms (Cancer) 12/2021 - 10/2008
4	Inflammation (Inflammations) 11/2014 - 05/2008
3	Iron Overload 06/2022 - 05/2008
3	Hepatocellular Carcinoma (Hepatoma) 06/2013 - 05/2008
2	Infections 06/2022 - 11/2014
2	Liver Neoplasms (Liver Cancer) 11/2016 - 11/2013
1	Bacteremia 06/2022
1	Obstructive Sleep Apnea 12/2021
1	Ischemia 10/2020
1	Neoplasm Metastasis (Metastasis) 10/2020
1	Carcinogenesis 02/2019
1	Fibrosis (Cirrhosis) 01/2019
1	Tuberous Sclerosis (Bourneville's Disease) 01/2018
1	Congenital Generalized Lipodystrophy (Berardinelli-Seip Congenital Lipodystrophy) 01/2018
1	Liver Diseases (Liver Disease) 01/2015
1	Biliary Liver Cirrhosis (Primary Biliary Cirrhosis) 01/2015
1	Sclerosing Cholangitis 01/2015
1	Autoimmune Hepatitis 01/2015
1	Non-alcoholic Fatty Liver Disease 01/2015
1	Psoriasis (Pustulosis Palmaris et Plantaris) 04/2013
1	Pathologic Processes 07/2012
1	Prostatic Neoplasms (Prostate Cancer) 01/2012
1	Hematologic Neoplasms (Hematological Malignancy) 01/2012
1	Uterine Cervical Neoplasms (Cancer of the Cervix) 07/2010
1	Renal Cell Carcinoma (Grawitz Tumor) 07/2010
1	Dermatitis 12/2009
1	Ovarian Neoplasms (Ovarian Cancer) 11/2008
1	Carcinoma (Carcinomatosis) 11/2008
1	Iron-Deficiency Anemia (Anemia, Iron Deficiency) 05/2008

Drug/Important Bio-Agent (IBA)

13	Oxygen (Dioxygen)IBA 12/2021 - 09/2010
11	Proteins (Proteins, Gene)FDA Link 10/2020 - 11/2004
8	Hypoxia-Inducible Factor 1IBA 04/2013 - 08/2006
7	Transcription Factors (Transcription Factor)IBA 01/2021 - 02/2008
5	IronIBA 06/2022 - 08/2006
5	CobaltIBA 11/2013 - 11/2004
4	HepcidinsIBA 06/2022 - 05/2008
4	Messenger RNA (mRNA)IBA 01/2015 - 05/2008
3	Erythropoietin FDA Link 12/2021 - 11/2013
3	Serine (L-Serine)FDA Link 01/2019 - 10/2010
3	CytokinesIBA 08/2013 - 01/2007
3	Pharmaceutical PreparationsIBA 06/2013 - 08/2006
2	Ferritins (Ferritin)IBA 06/2022 - 01/2015
2	EnzymesIBA 06/2022 - 01/2018
2	Peptides (Polypeptides)IBA 01/2021 - 02/2019
2	Glucose (Dextrose)FDA LinkGeneric 10/2020 - 07/2012
2	LipidsIBA 01/2019 - 01/2018
2	endothelial PAS domain-containing protein 1IBA 01/2019 - 11/2016
2	Triglycerides (Triacylglycerol)IBA 01/2018 - 07/2012
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2018 - 11/2004
2	AntioxidantsIBA 01/2018 - 03/2007
2	Interleukin-6 (Interleukin 6)IBA 08/2013 - 04/2013
2	FlavonoidsIBA 07/2010 - 03/2007
2	AntibodiesIBA 07/2010 - 12/2009
2	Chelating AgentsIBA 05/2008 - 08/2006
2	Deferoxamine (Desferal)FDA LinkGeneric 05/2008 - 08/2006
2	MetalsIBA 03/2007 - 08/2006
1	Anti-Bacterial Agents (Antibiotics)IBA 06/2022
1	ImmunosorbentsIBA 06/2022
1	ChromatinIBA 12/2021
1	Histones (Histone)IBA 12/2021
1	Cell-Penetrating PeptidesIBA 02/2019
1	Growth InhibitorsIBA 02/2019
1	Protein Kinases (Protein Kinase)IBA 01/2019
1	Carrier Proteins (Binding Protein)IBA 01/2019
1	CalcineurinIBA 01/2019
1	Phosphoprotein Phosphatases (Phosphatases, Protein)IBA 01/2019
1	Glycerophospholipids (Phosphoglycerides)IBA 01/2018
1	2-acylglycerophosphate acyltransferaseIBA 01/2018
1	Etoposide (VP 16)FDA LinkGeneric 01/2018
1	Small Interfering RNA (siRNA)IBA 01/2018
1	AcyltransferasesIBA 01/2018
1	Mechanistic Target of Rapamycin Complex 1IBA 01/2018
1	HexokinaseIBA 01/2017
1	mortalinIBA 01/2017
1	Casein Kinases (Casein Kinase)IBA 11/2016
1	Biomarkers (Surrogate Marker)IBA 05/2015
1	Antiviral Agents (Antivirals)IBA 11/2014
1	Protein Isoforms (Isoforms)IBA 11/2013
1	DNA (Deoxyribonucleic Acid)IBA 08/2013
1	Chemokine CCL5IBA 08/2013
1	mgcRacGAPIBA 06/2013
1	ElementsIBA 07/2012
1	lipineIBA 07/2012
1	AndrogensIBA 01/2012
1	Bortezomib (Velcade)FDA Link 01/2012
1	Proteasome InhibitorsIBA 01/2012
1	Peptide Initiation Factors (Initiation Factor)IBA 10/2010
1	Casein Kinase I (Casein Kinase 1)IBA 09/2010
1	kaempferolIBA 07/2010
1	Indicators and Reagents (Reagents)IBA 07/2010
1	Karyopherins (Importin)IBA 12/2009
1	Paclitaxel (Taxol)FDA LinkGeneric 11/2008
1	Carboplatin (JM8)FDA LinkGeneric 11/2008
1	Nuclear Export Signals (Nuclear Export Signal)IBA 10/2008

Therapy/Procedure

6	Therapeutics 01/2017 - 11/2008
3	Drug Therapy (Chemotherapy) 01/2017 - 07/2010
2	Radiotherapy 05/2015 - 10/2011
1	Aftercare (After-Treatment) 06/2022
1	Ligation 06/2015